The article proposes an aerocondensate technology for joint regulation of freshwater resources and climate for the purpose of large-scale water supply for the population, humidification of deserts and arid lands in Saudi Arabia, Africa and other climatically problematic regions. The technical and economic characteristics of the COOLERs megasystem with a capacity of waste-free industrial collection of freshwater condensate of up to 30 thousand tons/day and with the generation of high-altitude umbrella clouds of the cirrus type with a thickness of 0.5–2.0 km and a mass from 10 tons to several thousand tons are formulated to reduce solar radiation by 40% over an area of up to 100 thousand square kilometers to ensure access of humid marine atmospheric masses to the territory of deserts and the continent. Freshwater condensate is produced due to the presence of virtually unlimited and environmentally friendly atmospheric moisture of the seas and oceans by using a turbocompressor system for cooling the air during its adiabatic expansion. The basis for the implementation of the aerocondensate technology for regulating water resources and climate is the electrical energy of nuclear power plants and thermal power plants in problematic regions.