The paper considers installing vapor compression heat pumps at thermal power stations with the purpose of increasing the electrical power generation efficiency. All calculations were made for the Pravobereznaya CHPP-5 thermal power station of the Nevsky branch of the TGC-1 JSC. The calculations were made for heat pumps with different heat capacities of 2 MW and 50 MW. The efficiency of the heat pump system within the heat grid of the power station was analyzed through a detailed calculated estimate of the effect on the operating mode of the station with simultaneous calculation of the heat pump characteristics. The analysis was performed for different operating modes of the station. We proposed a scheme for using the heat pump for heating the make-up water in the heat supply system before it enters the vacuum deaerator. The cooling water located after the condenser on the combined cycle power unit is recommended as a low-energy heat source. Different alternatives of using the heat from the heat pump have been analyzed and the results demonstrate that the schematic application of heat pumps with the heat capacity of 50 MW to increase the heat generation in the heat supply system is commercially viable. The reference fuel economy runs at 57.3 thousands of tons per year and the payback time will be less than 2 years.