Except silicon dioxide, commonly used for DNA isolation, such metal oxides (V) as Ta2O5, Nb2O5 and V2O5 were proposed for this purpose. A method for covering magnetic iron-based nanoparticles with metal oxides (V) was suggested. The synthesized nanoparticles were used for DNA extraction and the amount of isolated DNA was compared with the commercially available magnetic particles coated with silicon dioxide. Magnetic nanoparticles covered with Ta2O5 and Nb2O5 showed- a greater adsorption capacity as compared with the same nanoparticles covered with silica and commercial samples. The synthesized nanoparticles can be suitable for DNA extraction in clinical or research laboratories. The functional thin films for fast and effective DNA extraction are of great interest for neurobiology investigations.