In this work some attempts were made to formalize concepts and principles with the help of mathematic formulas. Due to the formalization of chemical theory, various mathematical tools have been used to describe chemical processes. The basic types of formulas that should be contained in any physical and chemical theory were determined and the difference between chemical and mathematical axiomatics was shown. It is shown that any chemical system of elements can be represented as a system of equations expressing the state of the system + imposed restriction. As a rule, the state and impact on the system are expressed in the form of differential equations. It has been established that many mathematical equations do not always realistically describe chemical systems, in particular closed systems. Examples of calculation of glass formation area of complex glass-forming systems are given, with the help of mathematical modeling a comparison with experiment is made, and good convergence of the calculated and experimental glass formation regions is established.