The article analyzes the significant geometric parameters and the range of their variation in solving the optimization problem of centrifugal compressor impellers using computational fluid dynamics. The study was carried out using the Numeca Fine/Turbo package. The influence of more than 10 geometric parameters on the efficiency and the head of the impeller was considered. The influence of the degree of the investigated optimization parameters was estimated by changing the parameter values in a preset range and analyzing their impact on the efficiency and head of the impeller. As a result, the main geometric parameters of optimization, which should be considered first, were identified. Other parameters do not have to be considered within the optimization problem, and can be assigned standard values. In addition, recommendations on optimal ranges of parameter values were given.