Within the research devoted to improving the workflow of lubrication-free low-flow low-speed long-stroke piston compressors of medium and high pressure, we carried out experimental studies, which made it possible to substantiate the minimum number of cuff seals used to ensure a feed rate of at least 70%. To create an energy efficient machine, the required number of seals is seven. We analyzed the increase in the service life of cuff seals, which made it possible to give practical recommendations for the design of low-speed reciprocating compressors. Thus, to provide a service life of 100,000 hours, fourteen cuffs are needed: their gradual wear also provides a service life with the required level of feed rate. A further increase in the service life is possible with an increase in the number of seals, but this would increase the dimensions of the compressor stage as well.